Table 2

New and Updated Recommendations on Advanced Cardiac Life Support and Postarrest Care4,5,a

Therapeutic IssueRecommendationCORbLOEbType of Recommendation
Advanced Cardiac Life Support
 Timing of epinephrineAdminister as quickly as feasible for nonshockable rhythmsIIbC-LDUpdate
 Use of epinephrineSole vasopressor for shockable and nonshockable rhythmsIIbB-RUpdate
 Use of vasopressinRemoval from algorithm for shockable and nonshockable rhythmsIIbB-RUpdate
In-Hospital Cardiac Arrest
 Use of corticosteroidsShould be considered (in addition to vasopressin and epinephrine)IIbC-LDNew
 Use of targeted temperature management for nonshockable rhythmRecommended for adult comatose patientsIC-EOUpdate
Out-of-Hospital Cardiac Arrest
 Use of corticosteroidsBenefit unknownIIbC-LDNew
 Use of targeted temperature management for shockable rhythmRecommended for adult comatose patientsIB-RUpdate
Targeted Temperature Management
 DurationMinimum of 24 hrIIaC-EOUpdate
 Goal temperatureConstant at 32–36 °CIB-RNew
  • a COR = class of recommendation, LOE = level of evidence.

  • b Levels of classification and evidence defined in guideline summary.